
Proflavine Hemisulfate
CAS No. 1811-28-5
Proflavine Hemisulfate( Proflavine hemisulfate | Proflavine hemisulphate | EINECS 217-320-3 )
Catalog No. M12778 CAS No. 1811-28-5
Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
50MG | 30 | In Stock |
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100MG | 42 | In Stock |
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200MG | 54 | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameProflavine Hemisulfate
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NoteResearch use only, not for human use.
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Brief DescriptionProflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.
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DescriptionProflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.(In Vitro):Proflavine (0.1-10 μM; 24 hours) inhibits the growth of Kir3.2-transformant cells and Kir3.2 activity in a concentration-dependent manner.Proflavine (300 μM) progressively reduces the current amplitude of Kir3.2 mutant to 27.7±4.3% of the control.(In Vivo):Proflavine (0.1-10 μM; 24 hours) inhibits the growth of Kir3.2-transformant cells and Kir3.2 activity in a concentration-dependent manner.Proflavine (300 μM) progressively reduces the current amplitude of Kir3.2 mutant to 27.7±4.3% of the control.
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In VitroProflavine (0.1-10 μM; 24 hours) inhibits the growth of Kir3.2-transformant cells and Kir3.2 activity in a concentration-dependent manner. Proflavine (300 μM) progressively reduces the current amplitude of Kir3.2 mutant to 27.7±4.3% of the control. Cell Viability AssayCell Line:Kir3.2*-transformant BYT123 cells Concentration:0.1, 1, and 10 μM Incubation Time:24 hours Result:Dose-dependent inhibition of the growth of Kir3.2*-transformant cells. Attenuated the growth of Kir3.2*-transformant cells without affecting the growth of control cells.
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In VivoThe concentrations of Proflavine (20 mg/kg) in whole blood after intravenous injection decreased rapidly at the beginning and remained stable from around 30 min after dosing. Animal Model:Adult male Sprague Dawley rats (weighing approximately 200 g) Dosage:20 mg/kg (Pharmacokinetic Analysis) Administration:Intravenous injection; 2, 4, 5, 10, 15, 20, 25, and 30 min after dosing Result:Concentration decreased rapidly from whole blood in the first 5 min after dosing, followed by a slower decrease.
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SynonymsProflavine hemisulfate | Proflavine hemisulphate | EINECS 217-320-3
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA mutation| LfrR| QacR| Thrombin
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number1811-28-5
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Formula Weight516.57
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Molecular FormulaC26H24N604S
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Purity>98% (HPLC)
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SolubilityWater: 22 mg/mL (85.18 mM)
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SMILESC1=CC(=CC2=NC3=C(C=CC(=C3)[NH3+])C=C21)N.C1=CC(=CC2=NC3=C(C=CC(=C3)[NH3+])C=C21)N.[O-]S(=O)(=O)[O-]
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Chemical Name(6-aminoacridin-3-yl)azanium;sulfate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Stokowa K, et al. J Inorg Biochem, 2012, 106(1), 111-116.
molnova catalog



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